Wednesday , August 4 2021

Genetic advances make dreams and nightmares come true – GeekWire



He is Jiankui
Chinese researcher Jiankui discusses the lab's efforts to produce babies whose genes have changed to protect them from future HIV infection. (YouTube Lab)

In science, it was the best of times, and the worst of times.

2018 was a year when researchers focused on ways to get out of a disease by reprogramming the patient's own cells, but also crossing what many thought of as ethical red lines in genetic experiments. It was the first year that women had won some of the Nobel Prize for physics, as well as for chemistry, but also in the year when the subject Matteo, Is reflected in the scientific community.

And this was the year that marked the death of British physicist Stephen Hawking, who he claimed was the world's best-known scientist.

When I look back in 2018, I see some stories I missed but end up featuring other notable end of the year recaps. So, even the stuff, at the top of my ten list focuses on the five developments we have presented over the past 12 months, and another five that have not received much of a game at the same time. Feel free to use the comment section to post-in notes for science highlights of the year and low lights. (For example, a sad story of Tahlequah and residents of the South Arikas resident tops the Seattle Times end of year list):

Five breakthroughs in our participation

Infants who switched genes born in China: Last month, a genetic researcher announced that twin daughters were born with a genetically engineered mutation aimed at preventing them from getting the AIDS virus. The argument has raised concerns about opening a door to science fiction scenarios in which genetic traits change or improve to create the true equivalent of the comic book X Men (and Women). But since then, there has been a wave of rising questions about what he and his colleagues actually (or have not done). Their experiments have now been halted due to multiple investigations.

Immunotherapy takes a big hit: Techniques that accelerate the patient's immune system to fight cancer and other diseases have gained traction over the past year, thanks to a study aimed at maximizing the benefits of genetically modified cells while reducing negative side effects. Seattle is becoming such a center of research, thanks to Fred Hutchinson Cancer Center and the Biotechnology Center. The latest heroes of immunotherapy include gonadotropitis, Seattle genetics, amynx-terthepatitis, oncropping, and kinta. Next year, the Allen Institute for Immunology will join the campaign, commissioned by the institute's founder, Paul Allen, for $ 125 million.

Solving the Mystery of the Brain: The Allen Institute began 15 years ago with a focus on neuroscience, and in the past year has brought a series of advances. In March, researchers at the Institute revealed a publicly available database of computerized neural models that can be combined as lego blocks to simulate brain activity. In addition, the teachers participated in a project that became a new breed of human brain cells, and placed a "list of parts" for the brain in the study, presented on the cover of the journal Nature. Looking ahead, the Institute and its Allen boundaries will play roles in millions of dollars of effort focused on the connection between brain function and disease.

Going back and forth on climate change: More than a year after President Donald Trump announced that the United States would withdraw from the Paris climate agreement, there was another reason to worry about the climate. One study showed that global carbon dioxide emissions rise again after three relatively flat years. An analysis by the White House was contrary to Trump's views, and he adopted the effect of climate shifts on the region. Researchers from the University of Washington have contributed to studies documenting the loss of ice in Antarctica and following the role of ancient global warming in the planet's greatest extinction. Washington state voters rejected a plan to put a price on CO2 emissions, but the problem is to rise again in the months and years to come – at least if people like Microsoft co-founder Bill Gates and Washington J. Insley have all say on the subject.

Gets set to return to Titanic: Everett, Ushgate-based Osingate missed its schedule to bring mission researchers and experts (not calling them tourists!) To the ruins of Titanic this summer. But during this month's trials in the Bahamas, the OceanGate team, led by CEO Stockton Rush, successfully managed to dive test down to a depth of 4,000 feet (13,000 feet) Titanic level. Titanic's director, James Cameron, was the first.) The achievement moves Oceanic's Titan submarines to the Titanic orbit beginning next summer.

Five breakthroughs we missed

The struggle against crime in the blurred way … With DNA: Genealogy enthusiasts like me are not the only ones who take DNA tests. This year he saw a major catheter case in which researchers used genealogical experiments on the family to crack down on the murder of the 31-year-old Washington state. A DNA analysis of the archive helped the authorities narrow their search for a 55-year-old suspect arrested in Seattle in May, which led to the arrest in April of a suspect in the Golden State Killer case and more than a dozen other arrests, About 60% of White Americans, even if they have not personally submitted a DNA test.

Single Cell RNA Sequence: The journal "Science" details the technique of genetic analysis as its leading breakthrough for 2018. It involves the isolation of thousands of whole cells from living organisms, the sequencing of the genetic material in each cell, and then the reconstruction of cell relations in space and time. Single-cell RNA-seq can monitor how adult human cells are over life, how tissue regenerates, and what goes wrong when strike diseases. German biologist Nikolaus Regkowski told science that the method "will change the next decade of research."

The crater that killed the mammoth? Scientists have found traces of a massive impact crater beneath a half-mile thick layer of Greenland ice, thanks to the NASA IceBridge survey, and the 19-mile Hayawath Crater stands out not only for its size and technical analysis, Because it can address ongoing debate about the causes behind the disappearance of species such as mammoths and stodons. "The Junger Darias conjecture says that a comet explosion could have ignited a battlefield fire across North America 12,800 years ago and resulted in global cooling that killed the megapha and was derived from the culture of Not everyone is convinced that there is a connection between the hypothesis of Junger Darias and my heart Crater Hiiaooath, but the discovery has received a rating of ten stars of science as well as science news.

Tracking tangles in the family tree of humanity: The debate over the roots of our species, Homo sapiens, has been going on for years – but some findings reported this year demonstrate how much our family tree becomes. An ancient DNA contained in a 50,000-year-old Siberian fact provides evidence that two groups already extinct from the ancestors of Homo sapiens, known as Neanderthals and Danizovans, have been preserved, adding much evidence that humans and Neanderthals "did it" Thousands of years ago, another study shows that ancient Homo cousins ​​lived in China hundreds of thousands of years earlier, and many studies indicate that the Neanderthals were equal to the Homo sapiens in the artistic sense, contrary to the stereotype of the primitive caves.

New Archaeological Limits in Egypt: The stories that influenced my list reported a stream of archaeological finds in parts of Egypt that are off the beaten track – including a set of eight mummies of 2,300 years old in the dachas of southern Cairo and the pure of a 4,400 year old royal priest in Sakra. There were also some obvious errors: the discovery of a thousand-year-old sarcophagus that turned out to be full of ancient debris, and the assertion that King Tut's tomb does not contain a hidden room after all.

Year in space: The first launcher of a heavy Falcon to the last limit of the solar system


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