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The biological machines of the cell's "hangman" yield secrets of its control

Biological machines of

Tudor Moldoveanu, Ph.D., Associate Assistant in the Department of Structural Biology.

Researchers led by structural biologists at St. John's Hospital for Children's Research have discovered how cells pass through a mechanism of executioners called necroptosis that causes damaged or infected cells to commit suicide to protect the body.

Improper functioning of necroptosis also plays a role in the pathology of a variety of diseases. Cancer cells avoid destruction by inhibiting necrosis; And abnormal activation of necroticosis is associated with multiple sclerosis, Parkinson's disease and tissue damage from loss of blood flow. Thus, the researchers' basic findings open the way for treatment of drugs to treat these disorders by controlling bancroftosis.

Under the guidance of the structural biologist Tudor Moldovano, a doctor of structural biology, he included scientists from St. George's and Stanford University and Vanderbilt University of Medicine. The study was published today in the scientific journal Cell Biology Chemical.

Their study revealed how a group of molecules called inositol phosphates acts as an activation code, such as a combination into a safe, to release the cell killing mechanism of a molecule called MLKL. Activation activates the "hangman domain" of the MLKL molecule to break the integrity of the cell membrane and kill the cell.

The rescue protein gives cells determined to remain in the "execution"

more information:
Dan E. McNamara et al., Direct Activation of the Human MLKL By selecting a repertoire of Inositol phosphate metabolites, Cell Biology Chemical (2019). DOI: 10.1016 / j.chembiol.2019.03.010

Provided by
Children 's Research Hospital

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The biological machines of the cell's "hangman" yield secrets under its control (2019, April 26)
April 28, 2019

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