Clinical use against autoimmune diseases, allergies and cancer
"autoimmune diseases And allergies are among the most common emerging diseases in the world, and treatments are urgently needed. Here we are Discovery Be very useful. if you BH4 inhibits, we can inhibit the constant state of attack of these autaggressive cells so that they do not destroy healthy tissue or cause chronic inflammation, "he said. Shane Cronin, Postdoc at IMBA and the first author of the current publication at nature,
Clifford Wolf From Boston Children's Hospital Harvard and Kai-Johnson. Max Planck The Institute for Medical Research, Heidelberg, The researchers developed a new drug called QM385, BH4 inhibits, and Immune system cells With overreactions tame "tames". Initial clinical trials are declining.
BH4 also for cancer treatments?
BH4 At the same time it is also an important candidate for future cancer immunotherapies, as activated T cells reveal and fight cancer cells. The researchers found in mice that BH4 T cells help to focus the tumor. It also turned out that the emergence of BH4 Can be blocked by kynurenine, a molecule that immune system Can turn off tumors. Gift of BH4 Lets T cells grow again.
Valuable knowledge about relationships
"Knowledge of new relationships in biology and disease development is of great value because applications can be very versatile immune system Controlled by a molecule known for neurobiology and perhaps for new applications autoimmune diseases, Asthma can even lead to cancer and lack of vaccines! ", said Shane Cronin,
"If one manages to find connections of different biological systems in the body, as in this case the nervous system and immune system, You can sometimes amazing Discoveries Do. "In the past, it's about the team around Yosef Fenninger Using the example of the RANKL signaling pathway, the bone and hormone metabolism could be linked. The use of drug therapy as a result of denosumab range from bone loss to breast cancer pill, now