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Stem cells are complex in the patient's brain



Japanese researchers have injected "iPS" stem cells into the brain of a patient with Parkinson's disease. This clinical trial is designed to examine whether these cells can regenerate neurons in dopamine and relieve symptoms.

Team OfKyoto University Injected 2.4 million of these Pluripotent cells, Able to give any type of cell, in the left part of the the brain, During a three-hour operation last month. The man, in his fifties, was well tolerated, and now will be under surveillance for two years, the Kyoto University said in a statement.

If there is no problem during the next six months, the researchers will plant another 2.4 million cells, this time in the right part of the patient's brain. These iPS cells from healthy donors are expected to grow in Neurons Manufacturers of dopamine, a neurotransmitter involved in engine control.

In July, Kyoto University announced the holding of the clinical trial with seven participants aged 50 to 69 years. "I salute the patients for their courageous and determined participation", Said Prof. June Takahashi, quoted on Friday by the NHK television channel.

Pluripotent cells generate new neurons

Parkinson's disease Marked by degeneration of dopaminergic neurons and results in Symptoms Which gradually worsen such as tremors, stiffness of limbs and decreased body movements. It affects more than ten million people around the world, according to Parkinson 's USA Treatments Available Now "Improve symptoms without slowing progression of disease"Explains the basic.

This test follows an experiment conducted on monkeys with Stem cells Of human origin that improved the ability to perform movements Primates Suffers from Parkinson's disease, according to a study published in late August 2017 in the scientific journal nature. The survival of complex cells, by injection into the brain of primates, was observed for two years, with no Growth.

Induced pluripotent stem cells (iPS for Induced pluripotent stem cells) Are adult cells that were brought back to almost embryonic state by making them express four Genes (Usually inactive in adult cells). This genetic manipulation gives them the ability to produce any type cell (pluripotency), according to the place of the body where they are then transplanted. The use of iPS cells is not a basic ethical problem, unlike stem cells taken Passes humans.

What to remember

  • Scientists from the University of Kyoto injected 2.4 million pluripotent cells into the patient's brain.
  • These cells from healthy donors will have to renew dopamine neurons.
  • Overall, the clinical trial should include seven patients.

Parkinson's: Stem cells return the disease to monkeys

Article from Tokyo – AFP published on February 25, 2012

Monkeys in the development of the equivalent of Parkinson's disease Showed an improvement in their symptoms after injection into the brain of human stem cells. The technique can be tested in humans from 2015.

Monkeys with Parkinson's disease have made significant progress after transplanting human stem cells into their brains, Japanese researchers reported on Wednesday.

Four monkeys whose limbs moved convulsively (a common symptom syndrome of Parkinson 'sAnd those who struggled to control their bodies showed signs of improvement three months after surgery, said Jun Takahashi, a professor atKyoto University, One of the authors of the study published in Journal of Parkinson's Disease.

Six months later TransplantationThe four selected subjects could again walk in their cage, he added.

Jun Takahashi stated that while making, 35% Stem cells Had dopaminergic neurons, and about a tenth of them were still alive a year later. To improve the effectiveness of treatment, he wants to increase this survival rate to 70%. He hopes to be able to carry out this experiment on humans already in 2015. " First we need to increase the number of dopaminergic neurons graft, In order to reduce the risk Growth " After surgery, He explained.

Pluripotent stem cells induced in humans

In this experiment the monkey, Yoni Takahashi and his team used Embryonic stem cellsBut in the case of medical experience the researchers think they are using Induced pluripotent stem cells (IPSCs), created by transplanting four types of genes into human skin cells for reprogramming. These induced iPSCs thus generated to return almost to the embryonic stage (undifferentiated).

Use Embryonic stem cells, Which is considered very promising by many scientists, resists. Religious groups consider the culture of these cells to be immoral, stressing that Destruction of the fetus. In Japan, however, nothing prohibits the use of these cells for scientific research.

Parkinson's disease He's the main one Neurodegenerative diseasesafter Alzheimer's disease. This is also one of the most common causes of motor disability, after Accidents Cardiovascular disease.

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