Researchers at Northwestern University have identified a way to reprogram stem cells to treat diseases such as endometriosis, a condition in which endometrium, the lining of the inner wall of the uterus, grows in other parts of the body. This is the first time anyone can set up a protocol for reprogramming it.
The study, published in the scientific journal Stem Cell Reports, caused pluripotent stem cells to become healthy uterine cells from hormonal processes.
"The normal cells of the endometrium can be inserted into the uterine cavity to replace damaged cells." From there, we can solve the problem of progesterone resistance, and these cells can be used in the future to create a whole new uterus, "explains Sardar Boulogne, chief gynecologist of the study.
According to the Northwestern study, endometriosis is a disease that affects about 10% of women of childbearing age in the world, one of the most common causes of infertility. Endometriosis and infertility are related in 50% of cases, meaning that 50% of women with endometriosis have infertility and 50% of infertility cases in women may have endometriosis as a major factor.
What is endometriosis?
Every month, the ovaries produce hormones that stimulate endometrium cells to multiply and be ready to receive a fertilized egg. The mucosa increases in size and becomes thicker.
If these cells (called endometrial cells) grow out of the womb, endometriosis increases. Unlike cells that are normally found in the uterus, which are released during the menstrual cycle, the cells outside the uterus remain and grow in place.