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UFRJ discovers in the state of Rio mayaro virus, Ben David Of chicungunha



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RIO – Scientists from the Federal University of Rio de Janeiro
UFRJ
) Discovered a new circulating virus in the state of Rio.
virus
he
did
, Cousin of
chicungunha
And this causes the disease with symptoms similar to it, as intense and disabling
Pain
In the joints, which last months.

Since 2015, researchers have warned the risk that mayaro, the wild Amazon virus, establish itself in large cities in the southeast. A recent study shows that the worst happened. Mayaro is between us, says Rodrigo Brindiero, one of the members of Discovery and the center of the network
affinity
Of UFRJ. As in the case of chicungunha, there is no vaccine or treatment. Only symptoms are treated in a non-specific way.

Mayaro is known since 1950 in South and Central America. In Brazil it caused isolated outbreaks in the north and the Midwest. Moved by
Mosquito
forest
The Emagos
, Like wild fever yellow, he gave signs that he had begun to adapt to cities.

Laboratory tests have shown that it can be moved by both
Aedes
Some by
Steele
(third
ulex
), Which intensifies the risk of an epidemic, says Emileker Tanuri, coordinator of the Laboratory of Molecular Virology at UFRJ, where research was carried out.

Miaro's arrival increases the difficulty of controlling mosquito-borne diseases in a country that has been discharged into a sanitary abyss. By 2015, affinity epidemic had arrived, with microcephaly. Chicungunha, introduced in 2014, has expanded around the same time. The beginning of 2017 was characterized by the return of yellow fever to the southeast, with the largest wild form epidemic ever recorded in America.

This year began with the outbreak of dengue cases (an increase of 339.9% over the same period of 2018), a disease that returned in the eighties and did not disappear. According to the Ministry of Health, 994 Brazilian cities are at risk of relational epidemics, Dengi and Tsongone. Brindiero says that in Rio, chicungunha not alone mayaro may be the cause of some of the cases.

An outbreak that showed signs of urbanization in Santa Barbara, Pará, in 2008
Which cause diseases in the Amazon. Scientists categorize them by the type of milk syndrome they cause
The latest eruption in 2015
Graphic representation of the alphavirus, a classification that includes Mayaro and Chicungunha
Fabriella syndrome is an infection,
Classical fungus syndrome
In addition to high fever, can cause
(Fever, pain in the body,
A series of symptoms, ranging from outbreaks
Headache, vomiting, nausea, weakness)
Skin (rash) to inflammation in
Mucambo, Pixuna, Bussuquara Islands,
Brain (encephalitis) and bleeding. Oh
Dengue Virus 4, Capararo, guaroa,
The number and intensity of symptoms
tacaiuma, catu, guamá, apeu,
Varies from one patient to another
marituba, murucutu, oriboca, itaqui,
A virus can integrate more
nepuyo, alenquer, candiru, morumbi,
North, Uruppucha, Shingo, and Piri
Fabriella syndrome with rash
Mayarro, Chikunguna, Dengi and Zika
Rocio, dengue, tucunduba, ilheus,
Encephalitis, encephalitis
Venezuela, St. Louis Encephalitis

An outbreak that showed signs of urbanization in Santa Barbara, Pará, in 2008
The latest eruption in 2015
Which cause diseases in the Amazon. Scientists categorize them by the type of milk syndrome they cause
Graphic representation of the alphavirus, a classification that includes Mayaro and Chicungunha
Fever syndrome is an infection that, in addition to high fever, can cause a range of symptoms, ranging from skin rashes (rash) to inflammation of the brain (inflammation of the brain) and bleeding. The number and intensity of clinical symptoms vary from one patient to another, and a virus can fit into more than one class
Classical fungus syndrome
(Fever, pain in the body,
Headache, vomiting, nausea, weakness)
Mucambo, Pixuna, Bussuquara Islands,
Dengue Virus 4, Capararo, guaroa,
tacaiuma, catu, guamá, apeu, marituba,
Morocuto, oriboca, itaqui, nepuyo,
alenquer, candiru, morumbi, north sierra,
oropouche, xingu, piry and jurona
Fabriella syndrome with rash
Mayarro, Chikunguna, Dengi and Zika
Rocio, dengue, tucunduba, ilheus,
Encephalitis, encephalitis
Venezuela, St. Louis Encephalitis

The suffering and treatment of patients is the same. What changes is the difficulty in controlling the epidemics, with one more virus in circulation – explains Brindiero.

Confused with chicungunha, mayaro has been in Rio since 2016. And the seriousness of the discovery is that the cases are autochthonous. That is, people were infected here, they did not travel to endemic areas. There are three cases, all in Niteroi and only recognized thanks for molecular research. On a population scale, three chapters say that out of every 100 people with Chicungunha, 10 have fever mayaro, estimates Brindeiro.

– A partial report of Chicungunha himself is a major clinical diagnosis confused with that of Dengue. Our study is a warning about the severity of fever-preventing pigs, he adds.

Mayaro was identified at the peak of the affliction epidemic, when the UFRJ laboratory initiated the molecular diagnosis of an antibody that rotates in the southeast. In 2016, 279 samples had clinical indications (symptoms) of chicungunha. However, 57 gave inconclusive results.

Exceptions are expected because the PCR test only detects the virus during a short window of time (5 days in the blood and 20 days in the urine). However, the percentage of total cases reached 20%, much more than would be normal.

The study group began to look for other viruses, and Merow was found in three patients. The files were then investigated and found to have come from the same city, from people who had never been to Mayarro's Android regions and who had neighbors with similar symptoms. All three were negative by PCR (molecular) and by serology (antibodies in the blood) for zika, dengue and chicungunha, explains virologist Orlando Ferreira, head of serological tests.

The scientists' next step will be to find out where the virus came from in a genomic and serological analysis. One option is Amazon or Midwest mode. Otherwise she was brought from Haiti, where there was a plague recently. It could have come from immigrants or one of the military personnel who were part of the Brazilian forces in the UN service there.

They also hope to know if mayaro was distributed by the hamburger, which is very common in the forests and has proved to be effective in spreading Yellow Fever in Minas Rice, Espírito Santo, Rio de Janeiro. Niro Sao Paulo. Or, in a more serious hypothesis, began to spread by
Aedes
, By stilt or urban mosquitoes.

The mosquito can be detected by re-establishing the virus, a study by the UFRJ virologist Clarissa Damaso.

Without resources to expand research, scientists hope to analyze at least 400 samples this year from Mario, Maritsa and Miracema Municipalities. And they note the importance of looking for Mayaro in Rio's mosquitoes.

"We need to know what viruses are circulating in. The climate is positive for the spread of mosquitoes, which is a serious public health issue," says Ozzani.

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