Friday , January 22 2021

They create a gene that can prevent cancer from spreading



United States

A research team from the University of California, UCLA, Has developed a biodegradable spray With drugs that improve the immune system, in their experiments Prevent cancer from breeding In laboratory animals and prevented its spread to other parts of the body.

The spray not only inhibits the recurrence of tumors in the area of ​​the body from which they are produced, but also "controls the development of tumors in other parts of the body," according to the research director, a professor of bioengineering at the Samueli School of Engineering at UCLA. Johnson Comprehensive Cancer Center of the same university, Jin Gu.

The study Showed that many people are diagnosed with cancer Will undergo some type of surgery to treat your illness, Nearly 95% of patients with breast cancer Early diagnosis will require surgery, and usually, this is the first treatment line for people with a brain tumor. However, "despite the improvements in surgical techniques of the past decade, cancer often returns after the procedure," they warn from UCLA.

The researchers They tested the gene in mice that had advanced tumors Of melanoma removed surgically, when applied, the growth of remaining tumor cells after surgery has been reduced, helping to prevent recurrence of cancer. After receiving treatment, 50 percent of mice survived at least 60 days without their tumors and regrowing.

around 90% of people with cancerous tumors Eventually dying due to recurrent tumors or metastasis, Explanation from UCLA. So, Goo says, "This spray is promising against one of the biggest obstacles to cure cancer."

The researchers loaded nanoparticles with a targeted antibody, specifically, to block CD47, protein-releasing cancer cells. By blocking CD47, the antibody allows the immune system to find And finally, destroy the cancer cells.

Particles made of calcium carbonate, A component that can gradually dissolve in surgical wound sites and increase the activity of a macrophage type that "expels foreign objects from the body," according to Goo's postdoctoral researcher and lead author of the study, Jan Chen.

It was also noted that G-cell can activate T cells in the immune system to work together as another line of attack against ongoing cancer cells, Chen explains, which will have to be tested and approved before it can be used. – UCLA.

With information from the European press

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