Monday , January 18 2021

They solve the genetic mystery of jing



The puzzle of orange hair is much more complex than previously thought.

Until now the children were thought to have been born in Jin, having been inherited two copies of a gene called MC1R, One from the mother and another from his father.

The MC1R is a recessive gene, meaning that it can not be expressed in the presence of a dominant gene and only does so when the person receives the maternal and paternal copies.

However, not all people who inherited the MC1R gene have orange hair, so scientists suspected that other factors played an important role.

Which of these factors were a mystery … until now.

A study from Edinburgh University in the UK showed just why the MC1R gene explains only part of the puzzle.

Genetic differences

The study, developed by scientists at the University of Edinburgh, is More genetic research has been done on jing so far.

Other researchers in Scotland have tried to explain the key to orange hair.

Between 1 and 2% of the world's population is red-haired, but Scotland's percentage is close to 13%, that is 650,000 people, according to the ScotlandsDNA project.

Scientists from the University of Edinburgh have examined the DNA of nearly 350,000 people who participated in the so-called British project Great Britain, Which collects information on the genome health of more than 400,000 people in the UK.

When researchers compared the genome of jing to that of people with brown or black hair, they found eight differences associated with hair color.

And they also found it Some genes control when MC1R is pronounced or not.

Orange hair is not simply the result of a recessive gene, but of a complex interaction of At least eight genes.

Blond and brown

The researchers also found almost differences 200 genes Related to people with blond or dark hair.

There is a color that goes from black color, to dark brown, light brown and blond. And this gradient is caused by an increasing number of variants in those 200 genes.

Something that surprised the scientists is that many of these genetic differences are related not to pigmentation, but to the texture of the hair. Other variants determine how the hair grows, that is, whether it is straight or curly.

"Our work breaks down most of the genetic variations that contribute to hair color differences," he says. Albert Tansa, One of the researchers at the Rosslin Institute of the University of Edinburgh.

Ian C. Jackson, A genetic expert at the same center, said that the work is an example of "the strength of Britain and Biobank, a unique genetic study of the UK that allowed us to do these discoveries."

The study was published in the journal Nature Communications.



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