According to the director of the Institute of Chemistry Gregor Enderloh, ERC Advanced Grant 2018 called for more than 2050 requests for researchers, of which only 11% were selected for funding, indicating the Slovenian researcher's significant success.
However, with the assistance of the ERC Foundation at the Institute of Chemistry, a new research group has been established, which, according to Enderle, will be approximately 6 to 8 researchers from the Department of Molecular Biology and Nanobiotechnology. Part of the project will also be operated at University College London (UCL).
A five-year project titled RNP Dynamics will explore how regulation of RNA molecules contributes to the development and function of the brain and how errors in this teaching lead to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), a video researcher and professor of molecular neuroscience, he told a conference of ULE Videoconference.
In addition, the project will examine how malfunction of proteins and RNAs harms neurons and triggers ALS disease. This will be the basis for developing new strategies for treating diseases using RNA molecules.
According to Enderlech, this is a basic research project where they will not develop ALS drugs, but they will better understand the causes of the disease. "I am confident that the results of the project will be the basis for the development of drugs and strategies for the treatment of this disease in the future," said Enderle.
The study will be based on techniques that monitor all cellular networks of contact between the molecules, which will produce a large amount of data. These data will form the basis for computer analyzes to look for changes in molecular contact, which are the key to the dynamics of molecular complexes, leading to early brain development.
Researchers at the Institute of Chemistry will collaborate primarily in the field of structural biochemistry and structural chemistry, helping to understand the structure and interaction of the molecules and the computerized model of processes occurring in molecules in our bodies.
The Uletov project is the eighth project of the ERC, which is being carried out by the research organization in Slovenia and the fifth project of the program for established researchers. Is the second Slovenian ERC project at the Institute of Chemistry, the first entitled to MaCChines, last year by Roman Raleigh.
At today's event, Anderluh presented Marie Curie's projects Skodlowska actions – an individual scholarship program from India and Italy and research equipment, which will soon be installed in their laboratories.
As he said, this year, the Institute plans to modernize scientific research equipment within the National Center for High Resolution NMR Spectroscopy to acquire a new microelectric microelectric microscope that will be unique in the region. It will enable the study of structures of biological and complex macromolecules with atomic resolution, thereby "significantly enhancing life science research capabilities," said Enderle.
During the presentation of the microscope, a seminar will be held at the Institute of Chemistry, in which Nobel Prize winner Joachim Frank will also win. In 2017, he received the Nobel Prize in Chemistry for developing cryoelectronic microscopy along with researchers Jacques Dubochet and Richard Henderson.
The Slovenian researcher Rani Jola graduated from the Faculty of Biotechnology in Ljubljana and then received his doctorate at Rockefeller University in New York in 2004. In 2006 he set up a research team in England, first in Cambridge, and is now a professor of molecular neuroscience at UCL London, and leads the research team at the Francis Creek Institute.
In his PhD, he developed a new technique for this purpose called CLIP, and his team developed additional versions, such as iCLIP and hiCLIP, by examining how cells The brain regulates gene expression.