Tuesday , May 17 2022

Medical records from Taiwan, proof that herpes drugs can actually prevent Alzheimer's disease


Alzheimer's disease is the most common type of dementia of old age. A new study shows that the risk of developing Alzheimer's disease is closely related to people with herpes simplex virus (HSV-1) and carries specific genes.

The latest epidemiological data provide a causal link between HSV-1 and senile dementia, which provide simple and effective prophylaxis for one of the most harmful diseases in humans.

What causes Alzheimer's disease? Prof. Ruth Itzhaki, Professor & Ruth Yitzhaki responded in response: "The answer can be under your nose." Her recent research evidence suggests that the herpesvirus that causes cold sores may also cause Alzheimer's disease, and new data suggest that anti-blistering drug rash viruses can significantly reduce the risk of dementia in elderly patients with severe herpes infection.

HSV-1 theory of Alzheimer's disease

Although the current treatment of Alzheimer's disease is mainly to resolve the precipitation of β-protein amyloid protein (Aβ) and tau, according to the results of the current clinical trials, even if the Aβ precipitation is successfully reduced, the patient's brain function is also impossible to restore the original condition . The theory of viral pathogenesis of Alzheimer's disease has been developed for some time.

The herpes virus is a neurogenic virus that remains in our neurons and immune cells for life. When we are tired of stress or illness, it is active and is transmitted to the skin through the nerve axis to replicate virus viruses. Blisters are formed and cause skin irritation. It is estimated that 90% of people will be infected with HSV-1 by the age of 70, and viruses can be lurking in the body for decades.

"The incidence of Alzheimer's disease caused by HSV-1 may account for 50 percent or more," says Prof. Itzhaki. HSV-1 is better known for its ability to cause cold sores, and Itzhaki has previously shown that the incidence of cold sores is higher than APOE-ε4 bearing, and APOE-ε4 is an increase in Alzheimer's disease. Genetic variation at risk.

"Our theory suggests that among APOE-ε4 subjects, infected HSV-1 cells may be reactivated more frequently or more frequently, so that long-term cumulative damage eventually leads to the development of Alzheimer's disease."

How to prove the theory?

A small number of countries could collect enough demographic data to validate the theory, but the Taiwanese researchers were able to do so. Medical research units around the world have been very interested in whether anti-viral therapy can reduce the risk of dementia. The answer to this question seems to be ascertainable from the research results of Taiwan's research team.

In Taiwan, 99.9% of national medical information is sent to the National Health Insurance Database (commissioned by the National Health Service), and the database collects information on microbial infections and diseases.

During 2017 ~ 2018, there are three findings that describe the development of ancient dementia in Taiwan (where Alzheimer's disease is the leading cause of dementia among the elderly) and a significant infection with HSV-1 or Virosella zoster virus (VZV) results in treatment of patients.

The results show that people infected with HSV-1 are at a higher risk of senile dementia than the average person, and are 2.564 times higher. On the other hand, after receiving treatment for herpes, the number of people who develop HSV-1 to continue developing dementia is reduced by up to 90%.

Itzhaki's team provided findings supporting these epidemiological findings. They found that HSV-1 causes a specific deposit of a protein in Alzheimer's disease, which is the creation of signs between neurons.

"This viral DNA is specifically deposited in tissues of brain tissue after death in Alzheimer's patients. Major proteins of plaque can also accumulate in cultured cells infected with HSV-1, and anti-virus drugs can prevent this. Situation ".

Towards a cure

"The results of these studies in Taiwan apply only to abnormal infections of HSV-1 (or VZV), but ideally we should study the rate of dementia in people with mild HSV-1 infection, including lip," the authors note. Rash or mild genital herpes, but these patients are less likely to be included in the record. "

Although further research is needed to confirm the causal link between HSV-1 infection and Alzheimer's disease, Yitzhaki promises a future treatment.

"More than 150 studies have published support for the HSV-1 association with Alzheimer's disease, and the Taiwanese studies have shown that it is safe to use anti-herpes drugs to treat Alzheimer's disease." It is even more encouraging to develop the HSV-1 vaccine, which is probably the most effective treatment, "Yitzhaki said.

(Source: pixabay)

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