Monday , June 27 2022

Hope for women with ovaries without a cure: scientists discover the gene that causes it



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Hope for women with incurable ovaries: Scientists discover the gene behind the main cause of female infertility – paving the way for treatment

  • PCOS, the leading cause of infertility among women and type 2 diabetes, affects one in 10 women of childbearing age
  • The situation is also linked to weight gain, excessive hair growth and acne among women
  • A study revealed a gene involved in the male hormone called DENND1A plays a major role in the development of PCOS
  • The discovery can now lead to new treatment methods

A male gene that triggers abnormal testosterone levels in women can be the main cause of infertility, according to a new study.

A study of the causes of polycystic ovary syndrome (PCOS), which affects one in 10 women of childbearing age, found that DNA containing high levels of testosterone plays a key role in the condition.

PCOS, the leading cause of infertility among women and type 2 diabetes, affects one in 10 women of childbearing age.

The study, by scientists from Chicago and New York, is the first of its kind to use family-based genetic analysis to investigate the causes of PCOS.

The gene is important in the production of testosterone in the ovary – a major hormonal imbalance found in women with PCOS

The situation is also linked to weight gain, excessive hair growth and acne among women.

A study revealed a gene involved in the male hormone called DENND1A plays a major role in the development of PCOS.

The discovery can now lead to new treatment methods.

"PCOS is a major cause of female infertility and is associated with other serious health problems," said Dr. Andrea Donif of the Aiken University School of Medicine in Mount Sinai, New York.

"Our findings provide important new insights into the mechanisms by which genetic variants cause PCOS.

"The rare genetic versions that we found may be much better for predicting the situation than the common versions.

"Targeting pathways that are regulated by this gene can lead to new treatments for the condition."

Dr. Dunif studied the genetic basis of PCOS.

She and her team analyzed the DNA sequence of each genome from the authors of 62 families of women with PCOS.

Families who volunteered to be part of the study included both parents and one or more women of reproductive age with PCOS, as well as non-affected girls.

The genes were analyzed and the team discovered which genes contained variants that could damage women's ovaries.

Nearly half of the families were found to have rare genetic variants of the male gene, DENND1A, in their hormone and metabolic hormone levels.

The gene is important in the production of testosterone in the ovary – a key hormonal imbalance found in women with PCOS.

"Having sequenced the entire genome of many families affected by the disease, we have been able to study some of the rare genetic variants associated with PCOS," said Dr. Perry Hays, associate professor at Northwestern University.

"We hope our results will help uncover some of the genetic mechanisms involved and ultimately teach us more about the molecular drivers of the disorder."

The study began at the Northwestern University School of Medicine in Chicago and was completed at the Aiken University School of Medicine in New York.

The findings were published in the Journal of Clinical Endocrinology and Metabolism.

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