Saturday , October 1 2022

Is the bowel or brain more important in regulating appetite and metabolism?


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If the hormones of the gut or brain are more important for the regulation of appetite and metabolism is not clearly defined. An imbalance in appetite control and metabolism can lead to obesity and diabetes, which have a negative impact on human health and health costs. In a live discussion at the annual meeting of the Association of Endocrinology in Glasgow, leading experts will discuss this issue at a meeting titled "This House believes that the gut is the conductor of the Endocrine Orchestra." The experts will explore evidence supporting the functions of gut hormones and brain metabolism, and will discuss how best to target future research and treatment strategies for overweight and diabetic patients.

Obesity and diabetes are increasing global health epidemics and much attention is being paid to treating these disorders to avoid debilitating complications. Hormonal control of appetite and metabolism is complex and involved in a mix of brain and bowel hormones, including insulin, leptin, and galline. Releasing and controlling these hormones can be considered as an orchestra, with levels of each hormone changing rhythmically in response to each other. However, if the brain or intestines have more influence, as the conductor of the orchestra was not established. A better understanding of the integrated roles of the brain and intestinal hormones in controlling these functions may lead to improved targeting of research and development of more effective treatments for diseases such as obesity and diabetes.

In this discussion, experts Dr. Carel Le Roux and Dr. Yale Yao will examine the evidence for and against the brain or intestines as the brain behind the hormone of appetite and metabolism, and discuss implications for future research and treatment of the disease.

Dr. Carel Le Roux, a researcher in the investigative sciences of Imperial College in London, believes that the stomach turning to hormonal control in the body should be the focus when treating many hormonal imbalances and diseases.

According to Dr. Le Roux, "The intestines are the largest endocrine organ in the body, each time we eat the meal our body reacts by releasing a cocktail of gut hormones in a perfect concert to communicate with all our other organs."

He continues, "The intestines are now the main focus for finding therapeutic solutions to better treat type 1 and type 2 diabetes. The most successful treatments for obesity also use the strength of the intestines as an endocrine organ to cause and maintain weight loss.

However, Dr. Giles Yeo, principal research fellow of the MRC Metabolic Diseases Unit, University of Cambridge, disagrees and believes that the brain controls hormonal release by regulation of appetite and that without it most of the hormone signals released from the intestines when we eat would not Will take effect.

"Most of the genetic mutations that lead to developing patients are severe in the genes involved in the brain. Moreover, subtle variations in our genes associated with changes in the body mass index are often associated with genes in the brain."

Dr. Yao notes: "I agree that weight loss surgery changes the hormones released from the intestines, makes you feel fuller so that you eat less, but it is the brain that allows these changes, I believe that studying the genetics of how the brain reacts to hormones and regulates activity Can pave the way for the development of personalized medicine to treat very debilitating diseases such as obesity in the future. "

Explore further:
Hormone produced in appetite suppressant bones in mice

more information:
The discussion, "This House believes that the intestines is the conductor of the Endocrine Orchestra" will be presented by Carel Le Roux and Yao Yao at the Association of Endocrinology BES 2018 Conference on November 19, in Glasgow, UK.

Provided by:
Endocrinology Society

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